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    <loc>https://www.internationalstemcell.com/home</loc>
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    <lastmod>2022-05-11</lastmod>
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    <loc>https://www.internationalstemcell.com/company/management-team</loc>
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    <loc>https://www.internationalstemcell.com/pipeline</loc>
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    <lastmod>2022-05-09</lastmod>
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      <image:title>ISCO | Pipeline - THERAPEUTIC PIPELINE</image:title>
      <image:caption>ISCO scientists are using human parthenogenetic stem cells (hpSC) to treat severe diseases of the central nervous system, joints and liver, where cell therapy has shown clinical benefit but treatment options are limited by the availability of human cells. The hpSC are a promising therapeutic source because of their wide variety of treatment applications and ease of expansion. They also offer an abundant renewable resource, in contrast to scarce organ transplants and fetal tissue.</image:caption>
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      <image:title>ISCO | Pipeline - CYTOHEP</image:title>
      <image:caption>We have derived a homogenous population of hepatocyte-like cells (CytoHep) from hpSC. CytoHep was manufactured under cGMP with a novel method to derive high-purity definitive endoderm. Based on reproducing features of the normal human embryonic microenvironment, the highly enriched population of hepatocyte-like cells that are characterized by expression of hepatic lineage markers, indocyanine green clearance, glycogen storage, and cytochrome P450 activity (4,5). CytoHep can be used for the treatment of several liver diseases. Metabolic Liver Diseases Crigler-Najjar syndrome is a serious inherited metabolic liver disease where the liver lacks a critical enzyme responsible for processing the metabolic toxin bilirubin. The absence of this enzyme causes a build-up of bilirubin in the blood which can lead to brain and nerve damage. The most severe form of the syndrome results in early death; however, transplanting liver cells into a patient’s liver can help alleviate the symptoms of the disease. Our CytoHep behave similarly to primary hepatocytes. Implanting CytoHep in a pre-clinical animal model of Crigler-Najjar syndrome has shown positive benefits. CytoHep transplant lead to liver engraftment and a significant reduction of serum bilirubin levels compared with controls (6). Liver Cirrhosis Liver Cirrhosis is the scarring of the liver due to chronic hepatitis infection, alcoholism, autoimmune diseases, genetic diseases or enzymatic deficiencies. According to the National Institute on Alcohol and Alcoholism, cirrhosis is the 12th leading cause of death in the U.S. as of 2007, with 48% alcohol related. Roughly 17,000 people are awaiting liver transplants, with roughly 20% dying each year before a suitable donor can be found. CytoHep offers the possibility to generate a functional tissue utilizing our 3D bio-printing capabilities. In vitro, CytoHep expresses hepatic lineage markers and exhibits indocyanine green clearance, glycogen storage, and cytochrome P450 activity, and showed sustainable engraftment in a pre-clinical animal model, making it a leading candidate for tissue generation (4,5).</image:caption>
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      <image:title>ISCO | Pipeline - CHONDROSTEM</image:title>
      <image:caption>Osteoarthritis (OA) is a degenerative joint disease characterized by progressive erosion of the articular cartilage which leads to joint pain, stiffness, and impaired mobility. OA affects over 27 million Americans and the combination of arthritis and other rheumatic conditions have estimated medical costs of as much as $128 billion (Centers for Disease and Prevention 2007). Current cell therapy and tissue engineering therapeutic strategies for OA utilize expanded chondrocytes or autologous mesenchymal stem cells (MSCs). The differentiation protocols generate fibrocartilaginous tissues for transplantation which are mechanically defective. Our ChondroStem technology results in regenerating cartilage with enhanced cell viability by increasing the components involved in rebuilding cartilage: glycosaminoglycans, collagen type II, aggrecan and sulfated proteoglycans. We are utilizing 3D bio-printing capabilities to generate cartilage suitable for repair of damaged or osteoarthritic joints. We believe that ChrondroStem will be a superior therapeutic candidate for osteoarthritis and other rheumatic conditions.</image:caption>
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      <image:title>ISCO | Pipeline</image:title>
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  <url>
    <loc>https://www.internationalstemcell.com/manufacturing</loc>
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    <lastmod>2022-05-09</lastmod>
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      <image:title>ISCO | Manufacturing</image:title>
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  <url>
    <loc>https://www.internationalstemcell.com/science</loc>
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    <lastmod>2022-05-09</lastmod>
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      <image:title>ISCO | Science</image:title>
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      <image:title>ISCO | Science</image:title>
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  <url>
    <loc>https://www.internationalstemcell.com/company/overview</loc>
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    <priority>0.75</priority>
    <lastmod>2022-07-27</lastmod>
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  <url>
    <loc>https://www.internationalstemcell.com/company/board-of-directors</loc>
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    <lastmod>2022-07-27</lastmod>
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  <url>
    <loc>https://www.internationalstemcell.com/company/scientific-advisory-board</loc>
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    <lastmod>2022-05-09</lastmod>
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    <loc>https://www.internationalstemcell.com/company/subsidiaries</loc>
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    <priority>0.75</priority>
    <lastmod>2022-05-09</lastmod>
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      <image:title>ISCO | Subsidiaries - Lifeline cell technology</image:title>
      <image:caption>Our wholly-owned subsidiary Lifeline Cell Technology, LLC is a research products business which develops, manufactures and commercializes human cell culture products, including frozen human “primary” cells and the materials needed to grow, maintain and differentiate the cells. Lifeline Cell Technology’s products generally do not contain non-human animal material, a feature desirable with researcher working on human diseases. These research products are marketed and sold by our sales force, partners in the industry and an extensive number of distributors in Europe, Japan, China, Taiwan, Korea, India, Malaysia, Indonesia, Singapore, Middle East, New Zealand and Australia.</image:caption>
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      <image:title>ISCO | Subsidiaries - Lifeline Skin Care</image:title>
      <image:caption>Our wholly-owned subsidiary Lifeline Skin Care, Inc. is a cosmeceutical business which develops, manufactures and markets cosmetic skin care products using a proprietary extract derived from our human pluripotent stem cells that has been shown to have a beneficial effect on skin cells. Lifeline Skin Care cosmetic products are sold nationally and internationally through a branded website, various retailers such as Amazon, through dermatology and cosmetic surgery offices, medical, day and resort spas and a number of international distributors.</image:caption>
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  <url>
    <loc>https://www.internationalstemcell.com/contact-us</loc>
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    <lastmod>2022-05-18</lastmod>
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  <url>
    <loc>https://www.internationalstemcell.com/portfolio-1</loc>
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    <lastmod>2022-05-09</lastmod>
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  <url>
    <loc>https://www.internationalstemcell.com/portfolio-1/project-two-47n9r-pff8z</loc>
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    <lastmod>2020-01-29</lastmod>
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      <image:title>Portfolio 1 - Project Two</image:title>
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      <image:title>Portfolio 1 - Project Two</image:title>
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      <image:title>Portfolio 1 - Project Two</image:title>
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      <image:title>Portfolio 1 - Project Two</image:title>
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      <image:title>Portfolio 1 - Project Two</image:title>
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      <image:title>Portfolio 1 - Project Two</image:title>
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    <loc>https://www.internationalstemcell.com/portfolio-1/project-four-dhxrp-y9nn2</loc>
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    <lastmod>2020-01-29</lastmod>
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      <image:title>Portfolio 1 - Project Four - Make it stand out.</image:title>
      <image:caption>It all begins with an idea. Maybe you want to launch a business. Maybe you want to turn a hobby into something more. Or maybe you have a creative project to share with the world. Whatever it is, the way you tell your story online can make all the difference.</image:caption>
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    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5c5a514d65019f01a2cb2be5/1562685656804-Q9GBRN0NAL6DVNVQUCHS/20140301_Trade-151_0124-copy.jpg</image:loc>
      <image:title>Portfolio 1 - Project Four - Make it stand out.</image:title>
      <image:caption>It all begins with an idea. Maybe you want to launch a business. Maybe you want to turn a hobby into something more. Or maybe you have a creative project to share with the world. Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5c5a514d65019f01a2cb2be5/1562685656804-Q9GBRN0NAL6DVNVQUCHS/20140301_Trade-151_0124-copy.jpg</image:loc>
      <image:title>Portfolio 1 - Project Four - Make it stand out.</image:title>
      <image:caption>It all begins with an idea. Maybe you want to launch a business. Maybe you want to turn a hobby into something more. Or maybe you have a creative project to share with the world. Whatever it is, the way you tell your story online can make all the difference.</image:caption>
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    <loc>https://www.internationalstemcell.com/portfolio-1/project-six-r9psm-g64n3</loc>
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    <lastmod>2020-01-29</lastmod>
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      <image:title>Portfolio 1 - Project Six</image:title>
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      <image:title>Portfolio 1 - Project Six</image:title>
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      <image:title>Portfolio 1 - Project Six</image:title>
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      <image:title>Portfolio 1 - Project Six</image:title>
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  <url>
    <loc>https://www.internationalstemcell.com/portfolio-1/project-one-993mk-zsmmb</loc>
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    <priority>0.5</priority>
    <lastmod>2019-07-09</lastmod>
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      <image:title>Portfolio 1 - Project One</image:title>
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      <image:title>Portfolio 1 - Project One</image:title>
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      <image:title>Portfolio 1 - Project One</image:title>
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      <image:title>Portfolio 1 - Project One</image:title>
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      <image:title>Portfolio 1 - Project One</image:title>
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      <image:title>Portfolio 1 - Project One</image:title>
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    <loc>https://www.internationalstemcell.com/portfolio-1/project-three-b8g8x-923gw</loc>
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    <lastmod>2020-01-29</lastmod>
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      <image:title>Portfolio 1 - Project Three</image:title>
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      <image:title>Portfolio 1 - Project Three</image:title>
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      <image:title>Portfolio 1 - Project Three</image:title>
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      <image:title>Portfolio 1 - Project Three</image:title>
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      <image:title>Portfolio 1 - Project Three</image:title>
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    <loc>https://www.internationalstemcell.com/portfolio-1/project-five-ac44t-jl7cg</loc>
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    <lastmod>2020-01-29</lastmod>
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      <image:title>Portfolio 1 - Project Five</image:title>
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      <image:title>Portfolio 1 - Project Five</image:title>
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      <image:title>Portfolio 1 - Project Five</image:title>
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      <image:title>Portfolio 1 - Project Five</image:title>
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      <image:title>Portfolio 1 - Project Four - Make it stand out.</image:title>
      <image:caption>It all begins with an idea. Maybe you want to launch a business. Maybe you want to turn a hobby into something more. Or maybe you have a creative project to share with the world. Whatever it is, the way you tell your story online can make all the difference.</image:caption>
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    <image:image>
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      <image:title>Portfolio 1 - Project Four - Make it stand out.</image:title>
      <image:caption>It all begins with an idea. Maybe you want to launch a business. Maybe you want to turn a hobby into something more. Or maybe you have a creative project to share with the world. Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5c5a514d65019f01a2cb2be5/1562685656804-Q9GBRN0NAL6DVNVQUCHS/20140301_Trade-151_0124-copy.jpg</image:loc>
      <image:title>Portfolio 1 - Project Four - Make it stand out.</image:title>
      <image:caption>It all begins with an idea. Maybe you want to launch a business. Maybe you want to turn a hobby into something more. Or maybe you have a creative project to share with the world. Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
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      <image:title>Portfolio 1 - Project Two</image:title>
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      <image:title>Portfolio 1 - Project Two</image:title>
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      <image:title>Portfolio 1 - Project Two</image:title>
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      <image:title>Portfolio 1 - Project Two</image:title>
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      <image:title>Portfolio 1 - Project Two</image:title>
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    <lastmod>2020-01-29</lastmod>
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      <image:title>Portfolio 1 - Project Six</image:title>
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      <image:title>Portfolio 1 - Project Six</image:title>
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      <image:title>Portfolio 1 - Project Six</image:title>
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      <image:title>Portfolio 1 - Project Six</image:title>
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    <lastmod>2020-01-29</lastmod>
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      <image:title>Portfolio 1 - Project Three</image:title>
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    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5c5a514d65019f01a2cb2be5/1562691976953-8R4VZ8AMI4HOQ2I6VQC6/20140301_Trade-151_0124-copy.jpg</image:loc>
      <image:title>Portfolio 1 - Project Three</image:title>
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      <image:title>Portfolio 1 - Project Three</image:title>
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      <image:title>Portfolio 1 - Project Three</image:title>
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    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5c5a514d65019f01a2cb2be5/1562692032408-1PA4E708YJWGDKHIJBTL/20140301_Trade-151_0124-copy.jpg</image:loc>
      <image:title>Portfolio 1 - Project Three</image:title>
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    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5c5a514d65019f01a2cb2be5/1562692062669-4OIV3FJO1KMYZXSL1L7U/20140301_Trade-151_0124-copy.jpg</image:loc>
      <image:title>Portfolio 1 - Project Three</image:title>
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    <loc>https://www.internationalstemcell.com/portfolio-1-1/project-one-993mk-sbxzh</loc>
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    <lastmod>2019-07-09</lastmod>
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      <image:title>Portfolio 1 - Project One</image:title>
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    <image:image>
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      <image:title>Portfolio 1 - Project One</image:title>
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      <image:title>Portfolio 1 - Project One</image:title>
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      <image:title>Portfolio 1 - Project One</image:title>
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      <image:title>Portfolio 1 - Project One</image:title>
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      <image:title>Portfolio 1 - Project One</image:title>
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    <loc>https://www.internationalstemcell.com/portfolio-1-1/project-five-ac44t-ygm6z</loc>
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    <lastmod>2020-01-29</lastmod>
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      <image:title>Portfolio 1 - Project Five</image:title>
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      <image:title>Portfolio 1 - Project Five</image:title>
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      <image:title>Portfolio 1 - Project Five</image:title>
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      <image:title>Portfolio 1 - Project Five</image:title>
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